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Recognition of Double Helical DNA by Purine Oligonucleotides Via Triple Helix Formation

Recognition of Double Helical DNA by Purine Oligonucleotides Via Triple Helix Formation PDF Author: Peter A. Beal
Publisher:
ISBN:
Category :
Languages : en
Pages : 382

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Recognition of Double Helical DNA by Purine Oligonucleotides Via Triple Helix Formation

Recognition of Double Helical DNA by Purine Oligonucleotides Via Triple Helix Formation PDF Author: Peter A. Beal
Publisher:
ISBN:
Category :
Languages : en
Pages : 382

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Book Description


Antisense Research and Application

Antisense Research and Application PDF Author: Stanley T. Crooke
Publisher: Springer Science & Business Media
ISBN: 3642587852
Category : Medical
Languages : en
Pages : 630

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Book Description
Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.

Triple Helix Forming Oligonucleotides

Triple Helix Forming Oligonucleotides PDF Author: Claude Malvy
Publisher: Springer Science & Business Media
ISBN: 1461551773
Category : Science
Languages : en
Pages : 297

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Book Description
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Genetics of Common Diseases

Genetics of Common Diseases PDF Author: Ian Day
Publisher: Garland Science
ISBN: 1000102270
Category : Science
Languages : en
Pages : 344

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Book Description
Many common diseases are partly attributable to the genes which an individual inherits. Early steps have now been made in developing ways to determine which genetic variations are important, with some recent successes. This is a collection of papers from the Fifth Annual Molecular Pathology Symposium on the 10 December 1996. They represent the contributions to that meeting made by a set of distinguished scientists and clinicians whose work pertains to the furtherment of our understanding of the genetic components of common diseases and potential future approaches.

Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids PDF Author: Valery N. Soyfer
Publisher: Springer Science & Business Media
ISBN: 1461239729
Category : Science
Languages : en
Pages : 360

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Book Description
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Chemical Biology of Nucleic Acids

Chemical Biology of Nucleic Acids PDF Author: Volker A. Erdmann
Publisher: Springer Science & Business
ISBN: 3642544525
Category : Science
Languages : en
Pages : 599

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Book Description
This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Artificial Nucleases

Artificial Nucleases PDF Author: Marina A. Zenkova
Publisher: Springer Science & Business Media
ISBN: 364218510X
Category : Science
Languages : en
Pages : 292

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Book Description
The development of agents capable of cleaving RNA and DNA has attracted considerable attention from researchers in the last few years, because of the immediate and very important applications they can find in the emerging fields of biotechnology and pharmacology. There are essentially two classes of these agents - nucleases that occur naturally inside cells and synthetically produced artificial nucleases. The first class includes protein enzyme nucle ases and catalytic RNA structured ribozymes that perform cleavage of the phosphodiester bonds in nucleic acids according to a hydrolytic pathway in the course of different biochemical processes in the cell. A different pathway is used by some antibiotics which cleave DNA via redox-based mechanisms resulting in oxidative damage of nucleotide units and breakage of the DNA backbone. The above molecules are indispensable tools for manipulating nucleic acids and processing RNA; DNA-cleaving antibiotics and cytotoxic ribonucleases have demonstrated utility as chemotherapeutic agents. The second class, artificial nucleases, are rationally designed to imitate the active centers of natural enzymes by simple structures possessing minimal sets of the most important characteristics that are essential for catalysis. A dif ferent approach, in vitro selection, was also used to create artificial RNA and DNA enzymes capable of cleaving RNA. Being less efficient and specific as compared to the natural enzymes, the primitive mimics are smaller and robust and can function in a broad range of conditions.

Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids PDF Author: Valery N. Soyfer
Publisher: Springer Science & Business Media
ISBN: 9780387944951
Category : Medical
Languages : en
Pages : 384

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Book Description
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Light Metals—Advances in Research and Application: 2012 Edition

Light Metals—Advances in Research and Application: 2012 Edition PDF Author:
Publisher: ScholarlyEditions
ISBN: 1464990662
Category : Technology & Engineering
Languages : en
Pages : 1911

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Book Description
Light Metals—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Light Metals. The editors have built Light Metals—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Light Metals in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Light Metals—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Nucleic Acids Chemistry

Nucleic Acids Chemistry PDF Author: Ramon Eritja
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 311063953X
Category : Science
Languages : en
Pages : 380

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Book Description
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.