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Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids PDF Author: Valery N. Soyfer
Publisher: Springer Science & Business Media
ISBN: 1461239729
Category : Science
Languages : en
Pages : 360

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Book Description
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids PDF Author: Valery N. Soyfer
Publisher: Springer Science & Business Media
ISBN: 1461239729
Category : Science
Languages : en
Pages : 360

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Book Description
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Triple Helix Forming Oligonucleotides

Triple Helix Forming Oligonucleotides PDF Author: Claude Malvy
Publisher: Springer Science & Business Media
ISBN: 1461551773
Category : Science
Languages : en
Pages : 297

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Book Description
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Base Analogues and ligands for stabilising triple Helical Nucleic acids

Base Analogues and ligands for stabilising triple Helical Nucleic acids PDF Author: Richard Anthony James Darby
Publisher:
ISBN:
Category :
Languages : en
Pages : 153

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Triple Helical Nucleic Acid Interactions with Aminoglycoside Antibiotics

Triple Helical Nucleic Acid Interactions with Aminoglycoside Antibiotics PDF Author: R. Lane Coffee
Publisher:
ISBN:
Category :
Languages : en
Pages : 208

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Conformation and Stability of Mixed DNA Triplex

Conformation and Stability of Mixed DNA Triplex PDF Author: Tiwari Rakesh Kumar
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659478123
Category :
Languages : en
Pages : 220

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Book Description
DNA triple helices are formed by the binding of a third strand oligomer in the major groove of a Watson -Crick (WC) duplex. Interest in triple-helical nucleic acids-that is, triplex has been stimulated by the recognition of their potential biological roles and genetic applications. Although direct evidence of participation of triplexes in biological processes has not yet been obtained, there are ample data to suggest that triplexes can be involved in regulation of DNA replication, transcription, recombination and development.During DNA triplex formation third oligonucleotide strands binds with purine rich strand in major groove of DNA through Hoogsteen bindings. Third strands may be parallel or antiparallel to first strand. A further extension of this model is given for mixed-base-sequences in which third strand recognizes both the strands of DNA duplex through H-bonding (Mixed DNA triplex). In this manuscript a systematic study on the conformation and stability of mixed DNA triplexes and their possible structure in solution and in vacuum using computational techniques has been described. Which may be important for researchers and new comers.

Branched Nucleic Acids [microform] : Novel Probes for Studying Pre MRNA Processing and Triple Helical DNA

Branched Nucleic Acids [microform] : Novel Probes for Studying Pre MRNA Processing and Triple Helical DNA PDF Author: Ravinderjit Singh Braich
Publisher: National Library of Canada = Bibliothèque nationale du Canada
ISBN:
Category :
Languages : en
Pages : 350

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Branched Nucleic Acids, Novel Probes for Studying Pre MRNA Processing and Triple Helical DNA.

Branched Nucleic Acids, Novel Probes for Studying Pre MRNA Processing and Triple Helical DNA. PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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A Computational Study of Triple-strand Helical Nucleic Acids

A Computational Study of Triple-strand Helical Nucleic Acids PDF Author: Yuen-Kit Cheng
Publisher:
ISBN:
Category : DNA.
Languages : en
Pages : 450

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Applied Antisense Oligonucleotide Technology

Applied Antisense Oligonucleotide Technology PDF Author: Cy A. Stein
Publisher: Wiley-Liss
ISBN:
Category : Medical
Languages : en
Pages : 556

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Book Description
Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression. Chapters include oligonucleotide chemistry, DNA triplex formation, delivery mechanisms, pharmocokinetics, toxicity, oligonucleotides.

Nucleic Acids Chemistry

Nucleic Acids Chemistry PDF Author: Ramon Eritja
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110636484
Category : Science
Languages : en
Pages : 380

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Book Description
This book compiles recent research on the modification of nucleic acids. It covers backbone modifications and conjugation of lipids, peptides and proteins to oligonucleotides and their therapeutic use. Synthesis and application in biomedicine and nanotechnology of aptamers, fluorescent and xeno nucleic acids, DNA repair and artificial DNA are discussed as well.