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Triple Helix Forming Oligonucleotides

Triple Helix Forming Oligonucleotides PDF Author: Claude Malvy
Publisher: Springer Science & Business Media
ISBN: 1461551773
Category : Science
Languages : en
Pages : 297

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Book Description
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

Triple Helix Forming Oligonucleotides

Triple Helix Forming Oligonucleotides PDF Author: Claude Malvy
Publisher: Springer Science & Business Media
ISBN: 1461551773
Category : Science
Languages : en
Pages : 297

View

Book Description
Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.

A System for the Intracellular Generation of Triple Helix-forming Oligonucleotides (TFOs) and the Sequence-specific Inhibition of Human MCP-1 Gene Expression

A System for the Intracellular Generation of Triple Helix-forming Oligonucleotides (TFOs) and the Sequence-specific Inhibition of Human MCP-1 Gene Expression PDF Author: Kordula Kautz
Publisher:
ISBN:
Category :
Languages : en
Pages : 282

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Applied Antisense Oligonucleotide Technology

Applied Antisense Oligonucleotide Technology PDF Author: Cy A. Stein
Publisher: Wiley-Liss
ISBN:
Category : Medical
Languages : en
Pages : 556

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Book Description
Applied Antisense Oligonucleotide Technology provides the basic concepts as well as the practical concerns associated with the use of antisense oligonucleotides to modify gene expression. Chapters include oligonucleotide chemistry, DNA triplex formation, delivery mechanisms, pharmocokinetics, toxicity, oligonucleotides.

Mutagenic Properties of Psoralen-modified Triple Helix Forming Oligonucleotides

Mutagenic Properties of Psoralen-modified Triple Helix Forming Oligonucleotides PDF Author: Zoltán Sándor
Publisher:
ISBN:
Category : Oligonucleotides
Languages : en
Pages : 69

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Oligonucleotides as Therapeutic Agents

Oligonucleotides as Therapeutic Agents PDF Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470515406
Category : Science
Languages : en
Pages : 260

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Book Description
The use of oligonucleotides as therapeutic agents rests upon their ability to interfere, in a sequence-specific manner, with the fundamental machinery of protein synthesis either by binding to the mRNAs transcribed from a gene or by binding directly to a target gene. This approach can be used not only for inhibition of the synthesis of host proteins but also of those required by invading pathogens. Potential therapeutic applications are enormous, ranging over hypertension, cardiovascular disease, autoimmune disease, vital and other parasitic infections (especially HIV), and cancer. This book discusses the chemistry and pharmacokinetics of oligonucleotides and their analogues, and surveys the results of structure-activity studies and current clinical trials. It also critically reviews the problems with antisense therapy, such as the enzymatic destruction of oligonucleotides, the doses required for a therapeutic response, the difficulty in directing oligonucleotides to particular target tissues and cells, the need for parenteral administration, and doubts concerning the mechanism of action (especially problems associated with non-specific binding to proteins) and long-term effects.

Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids PDF Author: Valery N. Soyfer
Publisher: Springer Science & Business Media
ISBN: 9780387944951
Category : Medical
Languages : en
Pages : 384

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Book Description
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Antisense Research and Applications

Antisense Research and Applications PDF Author: Stanley T. Crooke
Publisher: CRC Press
ISBN: 9780849347054
Category : Medical
Languages : en
Pages : 620

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Book Description
Antisense Research and Applications is a comprehensive review of oligonucleotide research covering molecular biological advances in this field, the current status of antisense drug research, and strategies for future research and therapeutic applications. In bringing together the latest research from an array of authoritative scientists, Antisense Research and Applications provides an integrated conceptual basis for considering oligonucleotide therapeutics. Topics covered in the 32 chapters of this book include nucleic acid structure and function, antisense RNA, medicinal chemistry of oligonucleotides, analogs, pharmacokinetics and toxicology, and activities of current antisense drugs. This volume addresses advances in a broad range of disciplines and is an excellent resource for basic researchers and applied investigators in pharmaceutical laboratories and in such fields as biochemistry and molecular biology.

Modelling of Biomolecular Structures and Mechanisms

Modelling of Biomolecular Structures and Mechanisms PDF Author: A. Pullman
Publisher: Springer Science & Business Media
ISBN: 9401104972
Category : Science
Languages : en
Pages : 479

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Book Description
Gathering together a number of the best experts in the world, the 27th Jerusalem Symposium was devoted to the theme of the modelling of biomolecular structures and mechanisms. As a result of recent growth in both importance and audience, the papers contained in this volume present a thorough evaluation of the status of the present knowledge in this field. The main topics covered by this year's Symposium include nucleic acids and their interactions, proteins and their interaction, membranes and their interactions, enzymatic processes and the pharmacological and medical aspects of these subjects. Readers will benefit from the interdisciplinary approach which provides an extensive coverage of both theoretical and experimental advances.

Delivery Strategies for Antisense Oligonucleotide Therapeutics

Delivery Strategies for Antisense Oligonucleotide Therapeutics PDF Author: Saghir Akhtar
Publisher: CRC Press
ISBN: 9780849347788
Category : Medical
Languages : en
Pages : 324

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Book Description
With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Antisense Drug Technology

Antisense Drug Technology PDF Author: Stanley T. Crooke
Publisher: CRC Press
ISBN: 9780824705664
Category : Medical
Languages : en
Pages : 2004

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Book Description
This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds. Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes! Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses novel formulations of antisense drugs practical methods to design effective isotype selective inhibitors molecular mechanisms of antisense drugs mRNA as a current biological template modern postreceptor binding mechanisms and more! With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.